Pulmonary fibrosis (PF) is a disease in which excessive extracellular matrix (ECM) accumulation
occurs in the lungs, which induces thickening of the alveolar walls, ultimately leading to …

Myeloid cells such as monocytes and monocyte-derived macrophages promote tumor
progression. Recent reports suggest that extramedullary hematopoiesis sustains a sizable …

Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo
pathogenesis is largely unclear. Here, we generated a p16-Cre ERT2 -tdTomato mouse model to …

Interleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in multiple
cellular responses, including tumor development. However, the origin and functions of IL-11-…

CD8 + T cells are the key effector cells that contribute to the antitumor immune response. They
comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs). Thus…

Basophils are the rarest granulocytes and are recognized as critical cells for type 2 immune
responses. However, their differentiation pathway remains to be fully elucidated. Here, we …

Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like
monocyte expansion. However, their function, the committed precursors, or growth factors …

Pulmonary fibrosis is characterized by accumulation of activated fibroblasts that produce
excessive amounts of extracellular matrix components such as collagen type I. However, the …

Depletion of CD4 + cells in tumor-bearing mice has strong antitumor effects. However, the
mechanisms underlying these effects and the therapeutic benefits of CD4 + cell depletion …

The loss of nucleus pulposus (NP) precedes the intervertebral disk (IVD) degeneration that
causes back pain. Here, we demonstrate that the implantation of human iPS cell-derived …