User profiles for Shilpee Dutt

Shilpee Dutt

Principal Investigator at Tata Memorial Centre, ACTREC
Verified email at actrec.gov.in
Cited by 1968

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

S Dutt, A Narla, K Lin, A Mullally… - Blood, The Journal …, 2011 - ashpublications.org
Haploinsufficiency for ribosomal protein genes has been implicated in the pathophysiology
of Diamond-Blackfan anemia (DBA) and the 5q− syndrome, a subtype of myelodysplastic …

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

U Basu, J Chaudhuri, C Alpert, S Dutt, S Ranganath… - Nature, 2005 - nature.com
Antibodies, which are produced by B-lineage cells, consist of immunoglobulin heavy (IgH)
and light (IgL) chains that have amino-terminal variable regions and carboxy-terminal …

[HTML][HTML] Unique spectral markers discern recurrent Glioblastoma cells from heterogeneous parent population

…, N Gardi, A Dutt, A Moiyadi, CM Krishna, S Dutt - Scientific reports, 2016 - nature.com
An inability to discern resistant cells from bulk tumour cell population contributes to poor
prognosis in Glioblastoma. Here, we compared parent and recurrent cells generated from …

Nuclear localization of p65 reverses therapy-induced senescence

…, D Sarkar, J Rajendra, E Kaur, S Dutt - Journal of Cell …, 2021 - journals.biologists.com
Senescence is the arrest of cell proliferation and is a tumor suppressor phenomenon. In a
previous study, we have shown that therapy-induced senescence of glioblastoma multiforme (…

[PDF][PDF] BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response

Q Yan, S Dutt, R Xu, K Graves, P Juszczynski, JP Manis… - Molecular cell, 2009 - cell.com
Although the BBAP E3 ligase and its binding partner BAL are overexpressed in
chemotherapy-resistant lymphomas, the role of these proteins in DNA damage responses remains …

Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis

A Narla, S Dutt, JR McAuley… - Blood, The Journal …, 2011 - ashpublications.org
Corticosteroids and lenalidomide decrease red blood cell transfusion dependence in patients
with Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome (MDS), respectively. …

Raman spectroscopy‐based detection of RNA viruses in saliva: A preliminary report

…, S Dutt, MK Chilakapati, S Gupta, A Dutt - Journal of …, 2020 - Wiley Online Library
Several non‐invasive Raman spectroscopy‐based assays have been reported for rapid and
sensitive detection of pathogens. We developed a novel statistical model for the detection of …

Radiation-induced homotypic cell fusions of innately resistant glioblastoma cells mediate their sustained survival and recurrence

…, E Shridhar, JS Goda, A Moiyadi, S Dutt - …, 2015 - academic.oup.com
Understanding of molecular events underlying resistance and relapse in glioblastoma (GBM)
is hampered due to lack of accessibility to resistant cells from patients undergone therapy. …

[HTML][HTML] Versican V0 and V1 guide migratory neural crest cells

S Dutt, M Kléber, M Matasci, L Sommer… - Journal of biological …, 2006 - ASBMB
We previously showed the selective expression of the chondroitin sulfate proteoglycans
versican V0 and V1 in barrier tissues that impede the migration of neural crest cells during …

[HTML][HTML] Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation

…, S Dutt, PK Mishra, NK Khare, NK Nair, A Dutt - Cell Death …, 2017 - nature.com
Bystander cells of the tumor microenvironment show evidence of DNA damage and inflammation
that can lead to their oncogenic transformation. Mediator (s) of cell–cell communication …