Although genetic factors contribute to almost half of all cases of deafness, treatment options
for genetic deafness are limited 1 , 2 , 3 , 4 , 5 . We developed a genome-editing approach to …

Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is
characterized by increased serum bile acid and adverse fetal outcomes. The aetiology and …

Nonalcoholic steatohepatitis (NASH) has been linked with the gut-liver axis. Here, we
investigate the potential for repurposing disulfiram (DSF), a drug commonly used to treat chronic …

Terrestrial gamma-ray flashes (TGFs) are transient gamma-ray emissions from thunderstorms,
generated by electrons accelerated to relativistic energies in electric fields. Elves are …

To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a
genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 …

Aims It remains unknown whether the treatment of hypertension influences the mortality of
patients diagnosed with coronavirus disease 2019 (COVID-19). Methods and results This is a …

Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm
human healthcare. GC metastasis is one of the prime cause of failed cancer treatment, but …

Background The endoglycosidase heparanase which degrades heparan sulfate proteoglycans,
exerts a pro-inflammatory mediator in various inflammatory disorders. However, the …

Background Well-balanced interactions between gut microbiota and the immune system are
essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel …

Background Aberrant expression of circular RNAs contributes to the initiation and progression
of cancers, but the underlying mechanism remains elusive. Methods RNA-seq and qRT-…