Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNpc). An association has been reported between PD and …

NR3A is a developmentally regulated N‐methyl‐D‐aspartate receptor (NMDAR) subunit that
was previously known as NMDAR‐L or χ‐1. Unlike other NMDAR subunits, NR3A inhibits …

Recently, we cloned and began to characterize a newN-methyl-d-aspartate receptor (NMDAR)
subunit, NR3A. Here we extend our earlier findings by showing that recombinantly …

Hepatocellular carcinoma (HCC) is a major malignancy in many parts of the world, especially
in Asia and Africa. Loss of heterozygosity (LOH) on the long arm of chromosome 13 has …

Regulation of protein phosphatase 2A (PP2A) activity and NMDA receptor (NMDAR)
phosphorylation state contribute to the modulation of synaptic plasticity, yet these two mechanisms …

Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD),
and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy…

Sudden blockage of arteries supplying the heart muscle contributes to millions of heart
attacks (myocardial infarction, MI) around the world. Although re-opening these arteries (…

Background Mutations in the gene encoding parkin, a neuroprotective protein with dual
functions as an E3 ubiquitin ligase and transcriptional repressor of p53, are linked to familial …

Redox-mediated posttranslational modifications represent a molecular switch that controls
major mechanisms of cell function. Nitric oxide (NO) can mediate redox reactions via S-…

Emerging evidence suggests that supernumerary centrosomes drive genome instability and
oncogenesis 1 , 2 , 3 . Human T-cell leukaemia virus type I (HTLV-I) is etiologically …