Pancreatic ductal adenocarcinoma is refractory to available therapies. We have previously
shown that these tumors have elevated autophagy and that inhibition of autophagy leads to …

The “Warburg effect” describes a peculiar metabolic feature of many solid tumors, namely
their increased glucose uptake and high glycolytic rates, which allow cancer cells to …

Pancreatic ductal adenocarcinoma (PDA) remains a lethal human malignancy with historically
limited success in treatment. The role of aberrant Notch signaling, which requires the …

Background The Hedgehog (Hh) signalling pathway is overexpressed in pancreatic ductal
adenocarcinoma (PDA). Preclinical studies have shown that Hh inhibitors reduce pancreatic …

Activation of the receptor tyrosine kinase Axl is associated with poor outcomes in pancreatic
cancer (PDAC), where it coordinately mediates immune evasion and drug resistance. Here, …

Purpose: To identify effective metabolic inhibitors to suppress the aggressive growth of
pancreatic ductal adenocarcinoma (PDAC), we explored the in vivo antitumor efficacy of …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, with most patients facing
an adverse clinical outcome. Aberrant Notch pathway activation has been implicated in the …

Circadian rhythms are the daily oscillations of multiple biological processes regulated by an
endogenous clock. The Period2 gene is essential in controlling the circadian rhythm and …

KRAS is activated by mutation in the vast majority of cases of pancreatic cancer; unfortunately,
therapeutic attempts to inhibit KRAS directly have been unsuccessful. Our previous …

Purpose: Recent microarray and RNA-sequencing studies have uncovered aberrantly expressed
microRNAs (miRNA) in Barrett's esophagus–associated esophageal adenocarcinoma. …