Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic
inflammation and infectious diseases 1, 2, 3. Here we show that centenarians have a distinct gut …

Musashi is an evolutionarily conserved family of RNA-binding proteins that is preferentially
expressed in the nervous system. The first member of the Musashi family was identified in …

Axons in the adult mammalian central nervous system (CNS) exhibit little regeneration after
injury. It has been suggested that several axonal growth inhibitors prevent CNS axonal …

Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an important role
in axon guidance 1 , 2 , 3 , 4 , 5 . Previous studies have demonstrated that Sema3a −/− mice …

Although recent reports have described multipotent, self-renewing, neural crest-derived stem
cells (NCSCs), the NCSCs in various adult rodent tissues have not been well characterized …

Homologues of the Musashi family of RNA-binding proteins are evolutionarily conserved
across species. In mammals, two members of this family, Musashi1 (Msi1) and Musashi2 (Msi2)…

In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia.
Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is …

Astrocytes become reactive following various brain insults; however, the functions of reactive
astrocytes are poorly understood. Here, we show that reactive astrocytes function as …

Adrenal hypoplasia is a rare, life-threatening congenital disorder. Here we define a new
form of syndromic adrenal hypoplasia, which we propose to term MIRAGE (myelodysplasia, …

Nestin is an intermediate filament protein that is known as a neural stem/progenitor cell
marker. It is expressed in undifferentiated central nervous system (CNS) cells during …