User profiles for Shirish Shukla
 | Shirish ShuklaPost Doctoral Fellow at University of Michigan Verified email at umich.edu Cited by 2079 |
[HTML][HTML] Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells
Background- Specific types of high risk Human papillomaviruses (HR-HPVs) particularly,
HPV types 16 and 18 cause cervical cancer and while the two recently developed vaccines …
HPV types 16 and 18 cause cervical cancer and while the two recently developed vaccines …
Infection of human papillomaviruses in cancers of different human organ sites
Clinico-epidemiological and molecular studies have established the casual link between
Human Papillomavirus (HPV) infection and cervical cancer as also association of HPV infection …
Human Papillomavirus (HPV) infection and cervical cancer as also association of HPV infection …
[HTML][HTML] Anticancer property of Bryophyllum pinnata (Lam.) Oken. leaf on human cervical cancer cells
Background Bryophyllum pinnata (B. pinnata) is a common medicinal plant used in traditional
medicine of India and of other countries for curing various infections, bowel diseases, …
medicine of India and of other countries for curing various infections, bowel diseases, …
[HTML][HTML] Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection
Background Recent observations indicate potential role of transcription factor STAT3 in
cervical cancer development but its role specifically with respect to HPV infection is not known. …
cervical cancer development but its role specifically with respect to HPV infection is not known. …
Anticancer Activity of Phyllanthus emblica Linn. (Indian Gooseberry): Inhibition of Transcription Factor AP-1 and HPV Gene Expression in Cervical Cancer Cells
Plant products of Phyllanthus emblica Linn. are traditionally consumed for its immense nutritive
and medicinal values. However, the molecular mechanism(s) by which it exerts it effects …
and medicinal values. However, the molecular mechanism(s) by which it exerts it effects …
[HTML][HTML] Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis
Background Present study provides clinical evidence of existence of a functional loop involving
miR-21 and let-7a as potential regulators of aberrant STAT3 signaling recently reported …
miR-21 and let-7a as potential regulators of aberrant STAT3 signaling recently reported …
[HTML][HTML] Breast cancer and human papillomavirus infection: no evidence of HPV etiology of breast cancer in Indian women
Background Two clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically
associated with the development of cervical carcinoma and are also reported to be present …
associated with the development of cervical carcinoma and are also reported to be present …
Covalent inhibition of NSD1 histone methyltransferase
The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is
associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 …
associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 …
KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation
Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of
Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3:E2 complex …
Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3:E2 complex …
[HTML][HTML] Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis
Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor
constitutively active and aberrantly expressed in cervical cancer. However, the functional …
constitutively active and aberrantly expressed in cervical cancer. However, the functional …