Excessive collagen deposition by myofibroblasts during adverse cardiac remodeling leads
to myocardial fibrosis that can compromise cardiac function. Unraveling the mechanisms …

Abstract Knowledge of the causes of and mechanisms behind interappointment pain in
endodontics is of utmost importance for the clinician to properly prevent or manage this …

The incidences of cracks in teeth seem to have increased during the past decade. Dental
practitioners need to be aware of cracked tooth syndrome (CTS) in order to be successful at …

Molecular mechanisms underlying the diverse therapeutic effects of anti-diabetic metformin,
beyond its anti-hyperglycaemic effects, remain largely unclear. Metformin is reported to …

This study probed the largely unexplored regulation and role of fibronectin in Angiotensin II-stimulated
cardiac fibroblasts. Using gene knockdown and overexpression approaches, …

Cardiac fibroblasts contribute to multiple aspects of myocardial function and pathophysiology.
The pathogenetic relevance of cytokine production by these cells under hypoxia, however, …

Clinical pulpal anesthesia is dependent on the interaction of three major factors.(1) the dentist
(2) the patient and (3) local anesthesia. Many patients fear endodontic treatment due to a …

Relative resistance to apoptosis and the ability to proliferate and produce a collagen-rich
scar determine the critical role of cardiac fibroblasts in wound healing and tissue remodeling …

Collagen accumulation and remodeling in the vascular wall is a cardinal feature of vascular
fibrosis that exacerbates the complications of hypertension, aging, diabetes and …

Cardiovascular diseases are a leading cause of morbidity and mortality world-wide. While
many factors like smoking, hypertension, diabetes, dyslipidaemia, a sedentary lifestyle, and …