We report a genome-wide association study for open-angle glaucoma (OAG) blindness
using a discovery cohort of 590 individuals with severe visual field loss (cases) and 3,956 …

Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide.
We performed a genome-wide association study in an Australian discovery cohort …

Formation and differentiation of a pluripotent cell population is central to mammalian
development, and the isolation, identification and manipulation of human pluripotent cells is …

Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle
glaucoma (POAG), one of the leading causes of blindness worldwide 1 . Both IOP and POAG …

Extracellular vesicles and exomere nanoparticles are under intense investigation as
sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular …

Purpose.: Keratoconus is a progressive disorder of the cornea that can lead to severe visual
impairment or blindness. Although several genomic regions have been linked to rare …

Nance-Horan syndrome (NHS) is an X-linked disorder characterized by congenital cataracts,
dental anomalies, dysmorphic features, and, in some cases, mental retardation. NHS has …

Pseudoexfoliation syndrome is a generalized disorder of the extracellular matrix, characterized
by the pathological accumulation of abnormal fibrillar material in the anterior segment of …

The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal
organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial …

Background Exosomes, derived from endocytic membrane vesicles are thought to participate
in cell-cell communication and protein and RNA delivery. They are ubiquitous in most body …