The nuclear factor NF-κB and oncogenic Ras can alter proliferation in epidermis, the most
common site of human cancer 1 , 2 . These proteins are implicated in epidermal squamous …

Progenitor differentiation requires remodeling of genomic expression; however, in many
tissues, such as epidermis, the spectrum of remodeled genes and the transcription factors (TFs) …

Ras acts with other proteins to induce neoplasia. By itself, however, strong Ras signaling can
suppress proliferation of normal cells. In primary epidermal cells, we found that oncogenic …

ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing
differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis…

Somatic progenitors suppress differentiation to maintain tissue self-renewal. The mammalian
SWI/SNF chromatin-remodeling complex regulates nucleosome packaging to control …

NF-κB inhibition promotes epidermal tumorigenesis; however, whether this reflects an
underlying role in homeostasis or a special case confined to neoplasia is unknown. Embryonic …

Glucose is a universal bioenergy source; however, its role in controlling protein interactions
is unappreciated, as are its actions during differentiation-associated intracellular glucose …

Somatic progenitors sustain tissue self-renewal while suppressing premature differentiation.
Protein arginine methyltransferases (PRMTs) affect many processes; however, their role in …

A water-insoluble β-cyclodextrin (β-CD) polymer was synthesized by reacting β-CD with
hexamethylene diisocyanate, and its adsorption kinetics and thermodynamics for phenol from …

The c-Jun NH 2 -terminal kinase (JNK) signaling cascade has been implicated in a wide range
of diseases, including cancer. It is unclear how different JNK proteins contribute to human …