Muscle-invasive bladder cancers (MIBCs) are biologically heterogeneous and have widely
variable clinical outcomes and responses to conventional chemotherapy. We discovered …

Background It has been suggested that bladder cancer can be divided into two molecular
subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to …

Puerperal sepsis, a major cause of death of young women in Europe in the 1800s, was due
predominantly to the gram-positive pathogen group A Streptococcus Studies conducted …

Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit
STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary …

Lung adenocarcinoma (LUAD) has long been one of the predominant reasons for the global
cancer-linked mortality. The tumor progression is shown by several studies to be promoted …

Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths. …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Background Progression of conventional urothelial carcinoma of the bladder to a tumor with
unique microscopic features referred to as micropapillary carcinoma is coupled with …

The role of epigenetic regulation in immunity is emerging, especially for RNA N6‐methyladenosine
(m6A) modification. However, little is known about the role of m6A in the regulation of …

The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription factor
that modulates the transcription of several genes by binding to AT‑rich sequences in the …