Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies. The …

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer’s disease (AD)
have been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

In cortical regions of brains from individuals with preclinical or clinical Alzheimer's disease (AD),
extracellular β-amyloid (Aβ) deposition precedes the aggregation of pathological …

The endoplasmic reticulum (ER) stress response is regarded as an important process in the
aetiology of Alzheimer's disease (AD). The accumulation of pathogenic misfolded proteins …

Intraneuronal calcium stimulates the calpain-dependent conversion of p35 to p25, a CDK5
activator. It is widely believed that amyloid β peptide (Aβ) induces this conversion that, in turn, …

Variants of triggering receptor expressed on myeloid cells 2 (TREM2) are associated with an
increased incidence of Alzheimer’s disease, as well as other neurodegenerative disorders. …

To understand the molecular processes that link Aβ amyloidosis, tauopathy and
neurodegeneration, we screened for tau-interacting proteins by immunoprecipitation/LC-MS. We …

Endoplasmic reticulum (ER) stress is believed to play an important role in the etiology of
Alzheimer's disease (AD). The accumulation of misfolded proteins and perturbation of …

Base Editor (BE) and Target-AID (activation-induced cytidine deaminase) are engineered
genome-editing proteins composed of Cas9 and cytidine deaminases. These base-editing …

Although, a number of pathogenic mutations have been found for Alzheimer’s disease (AD),
only one protective mutation has been identified so far in humans. Here we identify possible …