Many patients suffering from developmental disorders harbor submicroscopic deletions or
duplications that, by affecting the copy number of dosage-sensitive genes or disrupting normal …

Background & Aims Identifying fibrosis in non-alcoholic fatty liver disease (NAFLD) is
essential to predict liver-related outcomes and guide treatment decisions. A protein-based …

Background Tissue inflammation in inflammatory bowel diseases [IBD] is associated with
local acidification. Genetic variants in the pH-sensing G protein-coupled receptor 65, also …

The roof plate-specific spondin–leucine-rich repeat-containing G-protein coupled receptor 4/5
(LGR4/5)–zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a …

Background and Aims A reduction in hepatic venous pressure gradient (HVPG) is the most
accurate marker for assessing the severity of portal hypertension and the effectiveness of …

Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an
increasing and substantial unmet medical need that urgently requires effective therapeutics. …

The multilineage differentiation capacity of mouse and human embryonic stem (ES) cells
offers a testing platform for small molecules that mediate mammalian lineage determination …

A limited understanding of the pathology underlying chronic wounds has hindered the
development of effective diagnostic markers and pharmaceutical interventions. This study aimed …

Background & Aims The Rspo-Lgr4/5-Znrf3/Rnf43 module is a master regulator of hepatic
Wnt/β-catenin signaling and metabolic zonation, but its impact on nonalcoholic fatty liver …

Aims and background: Identifying fibrosis in non-alcoholic fatty liver disease (NAFLD) is
essential to predict liver-related outcomes and inform treatment decisions. A protein-based …