TAR DNA-binding protein of 43 kDa (TDP-43) has been identified as the major component
of ubiquitin-positive neuronal and glial inclusions in frontotemporal lobar degeneration and …

Background The α‐Synuclein (α‐Syn) V15A variant has been found in two Caucasian
families with Parkinson's disease (PD). However, the significance of this missense variant …

Type 2 diabetes mellitus (T2DM) has long been considered a risk factor for Alzheimer’s
disease (AD). However, the molecular links between T2DM and AD remain obscure. Here, we …

The efficacy of current treatments is still insufficient for Alzheimer’s disease (AD), the most
common cause of Dementia. Out of the two pathological hallmarks of AD amyloid-β plaques …

In tauopathies, tau forms pathogenic fibrils with distinct conformations (termed "tau strains")
and acts as an aggregation "seed" templating the conversion of normal tau into isomorphic …

Variants in the microtubule-associated protein tau (MAPT) gene cause the genetic tauopathies,
a subgroup of frontotemporal dementia (FTD) disorders. Through genetic screening of …

Different conformational strains of tau have been implicated in the clinicopathological
heterogeneity of tauopathies. In this study, we hypothesized that distinct strains are degraded in a …

Background: Human tauopathy brain injections into the mouse brain induce the development
of tau aggregates, which spread to functionally connected brain regions; however, the …

α-Synuclein, a presynaptic protein, is involved in synaptic vesicle dynamics in response to
neuronal activity. Mutations of the α-synuclein gene and the neuronal deposition of α-…

To the Editor: Progressive supranuclear palsy (PSP) is characterized pathologically by abnormal
tau aggregates in neurons (neurofibrillary tangles [NFTs]), astrocytes (tufted astrocytes […