Foxp3 + regulatory T (T reg ) cells in visceral adipose tissue (VAT-T reg cells) are functionally
specialized tissue-resident cells that prevent obesity-associated inflammation and …

Loss of function of the tumor suppressor gene PRDM1 (also known as BLIMP1) or deregulated
expression of the oncogene BCL6 occurs in a large proportion of diffuse large B cell …

Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R),
but therapeutic success is limited. EGF-R is stimulated by soluble ligands, which are …

Most colon cancers arise from somatic mutations in the tumor suppressor gene APC (adenomatous
polyposis coli), and these mutations cause constitutive activation of the Wnt–to–β-…

Host IL11 Signaling Suppresses CD4+ T cell–Mediated Antitumor Responses to Colon
Cancer in Mice | Cancer Immunology Research | American Association for Cancer Research …

Colorectal cancers (CRCs) often display histological features indicative of aberrant
differentiation but the molecular underpinnings of this trait and whether it directly drives disease …

Doublecortin‐like kinase 1 (DCLK1) is a putative cancer stem cell marker, a promising
diagnostic and prognostic maker for malignant tumors and a proposed driver gene for gastric …

Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey
and play a critical role in maintaining the gastrointestinal epithelium. We show that cytotoxic …

Excessive signaling through gp130, the shared receptor for the interleukin ( IL )6 family of
cytokines, is a common hallmark in solid malignancies and promotes their progression. Here, …

The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most
colorectal cancers. A current limitation of inhibitors of this pathway is that they primarily induce …