Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
…, T Back, S Cramer, RM Dai, H Kiu, M Cardone, S Naik… - science, 2013 - science.org
The gut microbiota influences both local and systemic inflammation. Inflammation contributes
to development, progression, and treatment of cancer, but it remains unclear whether …
to development, progression, and treatment of cancer, but it remains unclear whether …
Compartmentalized control of skin immunity by resident commensals
S Naik, N Bouladoux, C Wilhelm, MJ Molloy, R Salcedo… - Science, 2012 - science.org
Intestinal commensal bacteria induce protective and regulatory responses that maintain host-microbial
mutualism. However, the contribution of tissue-resident commensals to immunity …
mutualism. However, the contribution of tissue-resident commensals to immunity …
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
The skin represents the primary interface between the host and the environment. This organ
is also home to trillions of microorganisms that play an important role in tissue homeostasis …
is also home to trillions of microorganisms that play an important role in tissue homeostasis …
[HTML][HTML] Trained immunity, tolerance, priming and differentiation: distinct immunological processes
The similarities and differences between trained immunity and other immune processes are
the subject of intense interrogation. Therefore, a consensus on the definition of trained …
the subject of intense interrogation. Therefore, a consensus on the definition of trained …
[HTML][HTML] GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
Tregs not only keep immune responses to autoantigens in check, but also restrain those
directed toward pathogens and the commensal microbiota. Control of peripheral immune …
directed toward pathogens and the commensal microbiota. Control of peripheral immune …
Inflammatory memory sensitizes skin epithelial stem cells to tissue damage
The skin barrier is the body’s first line of defence against environmental assaults, and is
maintained by epithelial stem cells (EpSCs). Despite the vulnerability of EpSCs to inflammatory …
maintained by epithelial stem cells (EpSCs). Despite the vulnerability of EpSCs to inflammatory …
Radioiodide imaging and radiovirotherapy of multiple myeloma using VSV (Δ51)-NIS, an attenuated vesicular stomatitis virus encoding the sodium iodide symporter …
…, KL Classic, S Greiner, S Naik… - Blood, The Journal …, 2007 - ashpublications.org
Multiple myeloma is a radiosensitive malignancy that is currently incurable. Here, we
generated a novel recombinant vesicular stomatitis virus [VSV(Δ51)-NIS] that has a deletion of …
generated a novel recombinant vesicular stomatitis virus [VSV(Δ51)-NIS] that has a deletion of …
Engineering oncolytic viruses to exploit tumor specific defects in innate immune signaling pathways
S Naik, SJ Russell - Expert opinion on biological therapy, 2009 - Taylor & Francis
Background: The use of oncolytic viruses for treatment of cancer marks a significant alteration
in the battle between host and virus. Viruses are confronted by cellular innate immune …
in the battle between host and virus. Viruses are confronted by cellular innate immune …
[PDF][PDF] Essential role for retinoic acid in the promotion of CD4+ T cell effector responses via retinoic acid receptor alpha
Vitamin A and its metabolite, retinoic acid (RA) are implicated in the regulation of immune
homeostasis via the peripheral induction of regulatory T cells. Here we showed RA was also …
homeostasis via the peripheral induction of regulatory T cells. Here we showed RA was also …
Compartmentalized and systemic control of tissue immunity by commensals
The body is composed of various tissue microenvironments with finely tuned local
immunosurveillance systems, many of which are in close apposition with distinct commensal niches. …
immunosurveillance systems, many of which are in close apposition with distinct commensal niches. …