Inflammation plays a role in the initiation and development of many types of cancers, including
epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of …

Background Platinum based agents—cisplatin and carboplatin in combination with taxanes
are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC …

This study establishes enteroendocrine progenitors as a targetable population that promotes
BRAF -mutant colorectal cancer and can be blocked by LSD1 inhibition to suppress tumor …

Colorectal cancers with BRAF mutations have distinct characteristics. We present evidence
of specific colorectal cancer gene–microbial interactions in which colonization with toxigenic …

Aberrant silencing of genes by DNA methylation contributes to cancer, yet how this process
is initiated remains unclear. Using a murine model of inflammation-induced tumorigenesis, …

Simple Summary Ovarian cancer is the deadliest amongst the gynecologic malignancies.
Most ovarian cancer patients initially respond to chemotherapy but will eventually relapse and …

Our data support the hypothesis that inhibitors targeting the CoREST complex may be
clinically effective in patients with colorectal cancer harboring PIK3CA mutations. …

Ovarian cancer (OC) is a lethal gynecological malignancy with a five-year survival rate of only
46%. Development of resistance to platinum-based chemotherapy is a common cause of …

… Sriramkumar dedicates this work in the loving memory of her mother Brinda Sriramkumar.
This research was funded by Ovarian Cancer Research Alliance grant number 458788 to HM …

… Riddhi Sood1, Sikai Xiao2, Shruthi Sriramkumar2, Christiane Hassel3, Kenneth P.
Nephew2,4,5, 3 … Sriramkumar S, Matthews TD, Ghobashi AH, Miller SA, VanderVere-Carozza …