User profiles for Shruti Nagaraja

Shruti Nagaraja

University of Michigan
Verified email at umich.edu
Cited by 231

[HTML][HTML] Utilization of Different Omic Approaches to Unravel Stress Response Mechanisms in the Parasite Entamoeba histolytica

S Nagaraja, S Ankri - Frontiers in Cellular and Infection Microbiology, 2018 - frontiersin.org
During its life cycle, the unicellular parasite Entamoeba histolytica is challenged by a wide
variety of environmental stresses, such as fluctuation in glucose concentration, changes in gut …

Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator

S Nagaraja, MW Cai, J Sun, H Varet, L Sarid… - Mbio, 2021 - Am Soc Microbiol
Queuosine is a naturally occurring modified ribonucleoside found in the first position of the
anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. Eukaryotes lack pathways to …

Target identification and intervention strategies against amebiasis

S Nagaraja, S Ankri - Drug Resistance Updates, 2019 - Elsevier
Entamoeba histolytica is the etiological agent of amebiasis, which is an endemic parasitic
disease in developing countries and is the cause of approximately 70,000 deaths annually. E. …

[HTML][HTML] Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate

…, C Shimokawa, M Trebicz-Geffen, S Nagaraja… - PLoS …, 2018 - journals.plos.org
Amebiasis, a global intestinal parasitic disease, is due to Entamoeba histolytica. This
parasite, which feeds on bacteria in the large intestine of its human host, can trigger a strong …

Comparative biochemical studies of disease-associated Human dicer mutations on processing of a pre-microRNA and snoRNA

RM Torrez, S Nagaraja, A Menon, L Chang, MD Ohi… - Biochemistry, 2023 - ACS Publications
Dicer is an RNase III enzyme that is responsible for the maturation of small RNAs such as
microRNAs. As Dicer’s cleavage products play key roles in promoting cellular homeostasis …

[HTML][HTML] Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to …

P Shahi, M Trebicz-Geffen, S Nagaraja… - PLoS neglected …, 2016 - journals.plos.org
Entamoeba histolytica is an obligate protozoan parasite of humans, and amebiasis, an
infectious disease which targets the intestine and/or liver, is the second most common cause of …

Infrared imaging of trauma patients for detection of acute compartment syndrome of the leg

LM Katz, V Nauriyal, S Nagaraj, A Finch… - Critical care …, 2008 - journals.lww.com
Objective: Early compartment syndrome is difficult to diagnose, and a delay in the diagnosis
can result in amputation or death. Our objective was to explore the potential of infrared …

[HTML][HTML] N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress

P Shahi, M Trebicz-Geffen, S Nagaraja, R Hertz… - Scientific reports, 2016 - nature.com
Adaptation of the Entamoeba histolytica parasite to toxic levels of nitric oxide (NO) that are
produced by phagocytes may be essential for the establishment of chronic amebiasis and the …

[HTML][HTML] Identification of S-Nitrosylated (SNO) Proteins in Entamoeba histolytica Adapted to Nitrosative Stress: Insights into the Role of SNO Actin and In vitro …

M Trebicz-Geffen, P Shahi, S Nagaraja… - Frontiers in cellular …, 2017 - frontiersin.org
We have recently reported that Entamoeba histolytica trophozoites can adapt to toxic levels
of the nitric oxide (NO) donor, S-nitrosoglutathione (GSNO). Even if the consequences of this …

Formation of oxidised (OX) proteins in Entamoeba histolytica exposed to auranofin and consequences on the parasite virulence

Y Shaulov, S Nagaraja, L Sarid… - Cellular …, 2020 - Wiley Online Library
Metronidazole (MNZ), the first line drug for amoebiasis and auranofin (AF), an emerging
antiprotozoan drug, are both inhibiting Entamoeba histolytica thioredoxin reductase. The nature …