Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

…, H Wu, JH Koh, WWB Goh, B George, SC Chong… - Journal of Cell …, 2020 - rupress.org
Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance
is implicated in metabolic diseases. Using an engineered sensor that activates the …

[HTML][HTML] Genome assembly and chemogenomic profiling of National Flower of Singapore Papilionanthe Miss Joaquim 'Agnes' reveals metabolic pathways regulating …

…, ZJ Low, PN Shingate, JH Hong, SC Chong… - Communications …, 2022 - nature.com
Singapore’s National Flower, Papilionanthe (Ple.) Miss Joaquim ‘Agnes’ (PMJ) is highly
prized as a horticultural flower from the Orchidaceae family. A combination of short-read …

Gastric bypass vs sleeve gastrectomy for type 2 diabetes mellitus: a randomized controlled trial

WJ Lee, K Chong, KH Ser, YC Lee, SC Chen… - Archives of …, 2011 - jamanetwork.com
Objectives To determine the efficacies of 2 weight-reducing operations on diabetic control
and the role of duodenum exclusion. Design Double-blind randomized controlled trial. Setting …

Comprehensive interactome analysis for the sole adenylyl cyclase Cyr1 of Candida albicans

G Zeng, SP Neo, LM Pang, J Gao, SC Chong… - Microbiology …, 2022 - Am Soc Microbiol
Cyr1, the sole adenylyl cyclase of the fungal pathogen Candida albicans , is a central
component of the cAMP/protein kinase A signaling pathway that controls the yeast-to-hypha …

Predicting the glycemic response to gastric bypass surgery in patients with type 2 diabetes

JB Dixon, LM Chuang, K Chong, SC Chen… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE To find clinically meaningful preoperative predictors of diabetes remission and
conversely inadequate glycemic control after gastric bypass surgery. Predicting the …

Changes in postprandial gut hormones after metabolic surgery: a comparison of gastric bypass and sleeve gastrectomy

WJ Lee, CY Chen, K Chong, YC Lee, SC Chen… - Surgery for Obesity and …, 2011 - Elsevier
BACKGROUND: Laparoscopic gastric bypass (GB) is reportedly more effective than laparoscopic
sleeve gastrectomy (SG) in the treatment of patients with a low body mass index and …

Laparoscopic sleeve gastrectomy for diabetes treatment in nonmorbidly obese patients: efficacy and change of insulin secretion

…, K Chong, YC Lee, SC Chen, JJ Tsou, JC Chen… - Surgery, 2010 - Elsevier
BACKGROUND: Sleeve gastrectomy is a new bariatric surgery, and many reports have
showed that patients who have undergone sleeve gastrectomy have experienced rapid …

Laparoscopic sleeve gastrectomy versus single anastomosis (mini-) gastric bypass for the treatment of type 2 diabetes mellitus: 5-year results of a randomized trial …

WJ Lee, K Chong, YH Lin, JH Wei, SC Chen - Obesity surgery, 2014 - Springer
Background Bariatric surgery may be beneficial in mildly obese patients with poorly controlled
diabetes. The optimal procedure to achieve diabetes remission is unknown. In 2011, we …

High incidence of secondary hyperparathyroidism in bariatric patients: comparing different procedures

JH Wei, WJ Lee, K Chong, YC Lee, SC Chen… - Obesity surgery, 2018 - Springer
Background Bariatric surgery is an effective therapy for morbid obesity but may reduce calcium
absorption and significantly decrease the bone mineral density. This study examined the …

C-peptide predicts the remission of type 2 diabetes after bariatric surgery

WJ Lee, K Chong, KH Ser, JC Chen, YC Lee, SC Chen… - Obesity surgery, 2012 - Springer
Background C-peptide is a surrogate of the pancreatic beta cell mass. However, the clinical
significance of C-peptide in a diabetic patient after bariatric surgery has not been studied …