In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for
injury and disease. Recent studies reported that ectopic expression or knockdown of certain …

Aims: Parkinson's disease (PD) heavily affects humans and little is known about its cause
and pathogenesis. Sirtuin 3 (Sirt3) plays a key role in regulating mitochondrial dysfunction, …

Aims: PTEN-putative kinase 1 (PINK1)-Parkin-mediated mitophagy is crucial for the
clearance of damaged mitochondria. However, the mechanisms underlying PINK1-Parkin-mediated …

Grain size is an important determinant of grain weight and yield in rice. Although several
genes related to grain size have been identified, natural variations in these genes that affect …

DYT1 dystonia is a hereditary neurologic movement disorder characterized by uncontrollable
muscle contractions. It is caused by a heterozygous mutation in Torsin A (TOR1A), a gene …

Key message A quantitative trait locus GW10 is located on Chromosome 10 by map-based
cloning, which encodes a P450 Subfamily protein. The GW10 regulates grain size and grain …

Amyloid plaques are crucial for the pathogenesis of Alzheimer disease (AD). Phagocytosis
of fibrillar β-amyloid (Aβ) by activated microglia is essential for Aβ clearance in Alzheimer …

Grain size is a key factor influencing grain yield and appearance quality in rice. We identified
twelve quantitative trait loci (QTL) for grain length (GL), nine for grain width (GW), and nine …

Background Alzheimer’s disease (AD) is an adult-onset mental disorder with aging as a
major risk factor. Early and progressive degeneration of basal forebrain cholinergic neurons (…

In vivo reprogramming of glia into functional neurons emerges as potential regeneration-based
therapeutics for neural injuries or neurological diseases. Recent studies show that AAV-…