Mutations to RAS proteins (H-, N-, and K-RAS) are among the most common oncogenic
drivers, and tumors harboring these lesions are some of the most difficult to treat. Although …

Asthma is a chronic inflammatory disease characterized by airway inflammation, mucus
hypersecretion and airway hyperresponsiveness. Mechanisms underlying the pathogenesis of …

Targeted degradation approaches such as proteolysis targeting chimeras (PROTACs) offer
new ways to address disease through tackling challenging targets and with greater potency, …

Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with
drug-like properties, including high-affinity target binding, protease resistance, and …

Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities
are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation …

An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide analogue that
hybridizes with the complementary mRNA in a sequence‐specific manner via Watson–Crick …

During neurogenesis, cell cycle regulators play a pivotal role in ensuring proper proliferation,
cell cycle exit, and differentiation of neural precursors. However, the precise role of cyclin-…

p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest,
senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between …

Rationale: Persistent activation of nuclear factor-κB has been associated with the development
of asthma. Glycogen synthase kinase-3β is known to regulate the activity of nuclear factor-…

Trisomy 21 (T21), Down Syndrome (DS) is the most common genetic cause of dementia
and intellectual disability. Modeling DS is beginning to yield pharmaceutical therapeutic …