Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways, homologous
recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 participates in …

Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic
inhibitors that block repair of DNA single-strand breaks (SSB). However, the mechanism of …

Repair of DNA double strand breaks (DSBs) plays a critical role in the maintenance of the
genome. DSB arise frequently as a consequence of replication fork stalling and also due to the …

Yeast rad51 mutants are viable, but extremely sensitive to γ-rays due to defective repair of
double-strand breaks. In contrast, disruption of the murine RAD51 homologue is lethal, …

Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent kinases
(CDKs) and their activating cyclin subunits. Based on pioneering findings that a dominant-…

The Rad51 protein, a eukaryotic homologue of Escherichia coli RecA, plays a central role in
both mitotic and meiotic homologous DNA recombination (HR) in Saccharomyces …

Sister chromatid exchange (SCE) frequency is a commonly used index of chromosomal stability
in response to environmental or genetic mutagens. However, the mechanism generating …

Anti-PARP drugs were initially developed as catalytic inhibitors to block the repair of DNA
single-strand breaks. We recently reported that several PARP inhibitors have an additional …

Constructs of four different genetic loci were transfected into the avian leukosis virus-induced
chicken B cell line DT40, which continues diversification of its rearranged light chain …

Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and mitochondrial
TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A and TOP3B) …