Aging is a major risk factor for many diseases including metabolic syndrome, cancer,
inflammation, and neurodegeneration. Identifying mechanistic common denominators underlying …

The amount and availability of proteins are regulated by their synthesis, degradation, and
transport. These processes can specifically, locally, and temporally regulate a protein or a …

One of the hallmarks of learning processes in any species studied so far is that they require
intact protein synthesis machinery in order to consolidate memories. Interestingly, synaptic …

An important tenet of learning and memory is the notion of a molecular switch that promotes
the formation of long-term memory 1 , 2 , 3 – 4 . The regulation of proteostasis is a critical …

BACKGROUND:: Mitochondria have been suggested to be involved in the pathology of
bipolar disorder (BD) and schizophrenia. However, the mechanism underlying mitochondrial …

mRNA translation, or protein synthesis, is a major component of the transformation of the
genetic code into any cellular activity. This complicated, multistep process is divided into three …

The senses of taste and odor are both chemical senses. However, whereas an organism
can detect an odor at a relatively long distance from its source, taste serves as the ultimate …

Evidence concerning ion-channel abnormalities in the pathophysiology of common
psychiatric disorders is still limited. Given the significance of ion channels in neuronal activity, …

Dopamine, alongside other neuromodulators, defines brain and neuronal states, inter alia
through regulation of global and local mRNA translation. Yet, the signaling pathways …

The current dogma suggests that the formation of long-term memory (LTM) is dependent on
protein synthesis but persistence of the memory trace is not. However, many of the studies …