Coarse-grained models have long been considered indispensable tools in the investigation
of biomolecular dynamics and assembly. However, the process of simulating such models is …

The need to protect public health during the current COVID-19 pandemic has necessitated
conference cancellations on an unprecedented scale. As the scientific community adapts to …

Tail-anchored (TA) membrane proteins, accounting for roughly 2% of proteomes, are primarily
targeted posttranslationally to the endoplasmic reticulum membrane by the guided entry …

The correct targeting and insertion of tail‐anchored (TA) integral membrane proteins is
critical for cellular homeostasis. TA proteins are defined by a hydrophobic transmembrane …

STI1‐domains are present in a variety of co‐chaperone proteins and are required for the
transfer of hydrophobic clients in various cellular processes. The domains were first identified in …

The targeting and insertion of tail-anchored (TA) integral membrane proteins (IMPs) into the
correct membrane is critical for cellular homeostasis. The fungal protein Sgt2, and its human …

… Shyam M Saladi … Shyam M Saladi Shyam M Saladi is a member of the eLife Early-Career
Advisory Group, and is in the Biochemistry and Molecular Biophysics Option, California Institute …

The heterologous expression of integral membrane proteins (IMPs) remains a major bottleneck
in the characterization of this important protein class. IMP expression levels are currently …

Integral membrane proteins (IMPs) control the flow of information and nutrients across cell
membranes, yet IMP mechanistic studies are hindered by difficulties in expression. We …

Homologs of the protein Get3 have been identified in all domains yet remain to be fully
characterized. In the eukaryotic cytoplasm, Get3 delivers tail-anchored (TA) integral membrane …