Complexin prevents SNAREs from releasing neurotransmitters until an action potential
arrives at the synapse. To understand the mechanism for this inhibition, we determined the …

10.7554/eLife.31013.001 Hearing relies on rapid, temporally precise, and sustained
neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This …

VAMP2 encodes the vesicular SNARE protein VAMP2 (also called synaptobrevin-2). Together
with its partners syntaxin-1A and synaptosomal-associated protein 25 (SNAP25), VAMP2 …

The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the
accessory helix extends away from the SNAREpin in an 'open' conformation, binding another …

The synaptic vesicle protein synaptotagmin-1 (SYT) is required to couple calcium influx to
the membrane fusion machinery. However, the structural mechanism underlying this process …

Mutations in proline-rich transmembrane protein 2 (PRRT2) are associated with a range of
paroxysmal neurological disorders. PRRT2 predominantly localizes to the pre-synaptic …

Neural networks are optimized to detect temporal coincidence on the millisecond timescale.
Here, we offer a synthetic hypothesis based on recent structural insights into SNARE s and …

Controlled release of neurotransmitters stored in synaptic vesicles (SVs) is a fundamental
process that is central to all information processing in the brain. This relies on tight coupling of …

10.7554/eLife.22964.001 Hormones and neurotransmitters are released through fluctuating
exocytotic fusion pores that can flicker open and shut multiple times. Cargo release and …

10.7554/eLife.17262.001 We recently reported that the C2AB portion of Synaptotagmin 1 (Syt1)
could self-assemble into Ca 2+ -sensitive ring-like oligomers on membranes, which …