Can the immune system be reactivated continuously throughout the lifetime of an organism
or is there a finite point at which repeated antigenic challenge leads to the loss of lymphocyte …

T cell senescence is thought to contribute to immune function decline, but the pathways that
mediate senescence in these cells are not clear. Here, we evaluated T cell populations from …

In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic
functions and is activated by canonical MAPK signaling or the alternative activation pathway …

Highly differentiated CD8 + CD28 − CD27 − T cells have short telomeres, defective telomerase
activity, and reduced capacity for proliferation, indicating that they are close to replicative …

As humans live longer, a central concern is to find ways to maintain their health as they age.
Immunity declines during ageing, as shown by the increased susceptibility to infection by …

Persistent viral infections and inflammatory syndromes induce the accumulation of T cells
with characteristics of terminal differentiation or senescence. However, the mechanism that …

T cells undergo profound metabolic changes to meet the increased energy demands of
maintaining an antiviral response. We postulated that differences in metabolic reprogramming …

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells
and antigen-experienced T cells and has been postulated to be a marker of senescence. …

Cellular senescence is accompanied by a senescence‐associated secretory phenotype (
SASP ). We show here that primary human senescent CD 8 + T cells also display a SASP …

Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation
of highly differentiated CD45RA re-expressing memory T cells. These cells increase during …