[HTML][HTML] Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis

…, E Belonovskaya, O Lukivskaya, E Naruta, S Kirko… - PLoS …, 2020 - journals.plos.org
Background and aims Alcoholic steatohepatitis (ASH)—the inflammation of fatty liver—is
caused by chronic alcohol consumption and represents one of the leading chronic liver …

[HTML][HTML] Chlorogenic acid protects against advanced alcoholic steatohepatitis in rats via modulation of redox homeostasis, inflammation, and lipogenesis

…, G Budryn, M Zakłos-Szyda, E Belonovskaya, S Kirko… - Nutrients, 2021 - mdpi.com
The aim of this study was to evaluate the therapeutic effects of chlorogenic acid (CGA) in rats
with advanced alcoholic steatohepatitis. The rats were fed on a high-fat diet and gavaged …

Betulin/2-hydroxypropyl-β-cyclodextrin inclusion complex: Physicochemical characterization and hepatoprotective activity

…, I Zavodnik, B Palecz, A Stepniak, S Kirko… - Journal of Molecular …, 2020 - Elsevier
The thermodynamic and spectroscopic parameters of the betulin/2-hydroxypropyl-β-cyclodextrin
(HPβCD) inclusion complex and its hepatoprotective activity were investigated in rats …

Ursodeoxycholic acid dose‐dependently improves liver injury in rats fed a methionine‐and choline‐deficient diet

…, EE Naruta, OY Lukivskaya, SN Kirko… - Hepatology …, 2011 - Wiley Online Library
Aim: The data on the beneficial effect of ursodeoxycholic acid (UDCA) in non‐alcoholic
steatohepatitis (NASH) are controversial. The difference of opinion is connected with UDCA …

Cranberry (Vaccinium macrocarpon) peel polyphenol-rich extract attenuates rat liver mitochondria impairments in alcoholic steatohepatitis in vivo and after oxidative …

…, E Lapshina, T Ilyich, E Belonovskaya, S Kirko… - Journal of functional …, 2019 - Elsevier
Alcoholic steatohepatitis is an important medical problem but its effective therapies are still
not available. Plant polyphenols are widely used for prevention of toxic liver damages. The …

A piglet with surgically induced exocrine pancreatic insufficiency as an animal model of newborns to study fat digestion

…, SG Pierzynowski, D Grujic, S Kirko… - British Journal of …, 2014 - cambridge.org
The maldigestion and malabsorption of fat in infants fed milk formula results due to the minimal
production of pancreatic lipase. Thus, to investigate lipid digestion and absorption and …

ω‐Imidazolyl‐alkyl derivatives as new preclinical drug candidates for treating non‐alcoholic steatohepatitis

…, O Lukivskaya, E Naruta, S Kirko… - Physiological …, 2021 - Wiley Online Library
Cytochrome P450 2E1 (CYP2E1)‐associated reactive oxygen species production plays an
important role in the development and progression of inflammatory liver diseases such as …

Enhanced absorption of long-chain polyunsaturated fatty acids following consumption of functional milk formula, pre-digested with immobilized lipase ex vivo, in an …

K Goncharova, S Kirko, D Grujic, M Kardas… - Journal of functional …, 2017 - Elsevier
An exocrine pancreatic insufficient (EPI) pig model was used in the study. The effects of milk
formula pre-digestion with immobilized microbial lipase, on the absorption and tissue …

[HTML][HTML] A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma

…, C Renz, R Dvorsky, V Buko, S Kirko… - Canadian Journal of …, 2021 - hindawi.com
Cytochrome P450 2E1 (CYP2E1) is a key target protein in the development of alcoholic and
nonalcoholic fatty liver disease (FLD). The pathophysiological correlate is the massive …

ω-imidazolyl-alkyl derivatives as new preclinical drug candidates for NASH therapy

…, E Belonovskaya, O Lukivskaya, E Naruta, S Kirko… - bioRxiv, 2019 - biorxiv.org
Cytochrome P450 2E1 (CYP2E1) and its production of ROS play an essential role in the
development and progression of inflammatory liver diseases such as alcoholic steatohepatitis. …