Aberrations in post-translational modifications of histones have been shown to occur in cancer
cells but only at individual promoters 1 ; they have not been related to clinical outcome. …

The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …

Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by
targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted …

Histone acetyltransferases and deacetylases with specificities for different sites of acetylation
affect common chromatin regions. This could generate unique patterns of acetylation that …

Cancer cells exhibit alterations in histone modification patterns at individual genes and
globally at the level of single nuclei in individual cells. We demonstrated previously that lower …

Yeast contains a family of five related histone deacetylases (HDACs) whose functions are
known at few genes. Therefore, we used chromatin immunoprecipitation and intergenic …

Histone deacetylases, typified by class I Rpd3 in the yeastSaccharomyces cerevisiae, have
historically been associated with gene repression. We now demonstrate that Hos2, another …

We describe the genome-wide distribution of the histone deacetylase and repressor Rpd3
and its associated proteins Ume1 and Ume6 in Saccharomyces cerevisiae. Using a new cross…

Through a differential screening technique, we have identified a cDNA clone with differential
expression in normal versus tumor cells. This clone, designated rit42 (reduced in tumor, 42 …

Differences in global levels of histone acetylation occur in normal and cancer cells, although
the reason why cells regulate these levels has been unclear. Here we demonstrate a role …