MicroRNAs (miRNA) are short (~22nt) single stranded RNAs that downregulate gene
expression. Although recent studies indicate extensive miRNA changes in response to ischemic …

Mitochondria are central to the execution of apoptosis, and the Bcl-2 protein family of pro-
and anti-apoptotic proteins interacts with mitochondria to regulate apoptosis. Using …

Lamins are structural components of the nuclear lamina (NL) that regulate genome organization
and gene expression, but the mechanism remains unclear. Using Hi-C, we show that …

Following transient forebrain ischemia, astrocytes play a key role in determining whether or
not neurons in the hippocampal CA1 sector go on to die in a delayed fashion. MicroRNAs (…

Background Mature miRNAs can often be classified into large families, consisting of
members with identical seeds (nucleotides 2 through 7 of the mature miRNAs) and highly …

Oncogenes, which are essential for tumor initiation, development, and maintenance, are
valuable targets for cancer therapy. However, it remains a challenge to effectively inhibit …

Astrocytes have been shown to protect neurons and increase their survival in many
pathological settings. Manipulating astrocyte functions is thus an important strategy to enhance …

Defects in cellular proteostasis and mitochondrial function drive many aspects of infertility,
cancer, and other age-related diseases. All of these conditions rely on quiescent cells, such …

Abstract Changes in maternal diet and metabolic defects in mothers can profoundly affect
health and disease in their progeny. However, the biochemical mechanisms that induce the …

Understanding how chromatin modification regulates development and disease can be
limited by available material. Despite recent progress, balancing high-quality and reliable …