Mesenchymal cells contribute to the ‘stroma’ of most normal and malignant tissues, with
specific mesenchymal cells participating in the regulatory niches of stem cells. By examining …

Mutations in PIK3CA, which encodes the p110α subunit of the insulin-activated
phosphatidylinositol-3 kinase (PI3K), and loss of function mutations in PTEN, which encodes a …

… Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! Physician,
researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer …

Cells of the osteoblast lineage affect the homing 1 , 2 and the number of long-term repopulating
haematopoietic stem cells 3 , 4 , haematopoietic stem cell mobilization and lineage …

The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, …

Drug targeting of adult stem cells has been proposed as a strategy for regenerative medicine,
but very few drugs are known to target stem cell populations in vivo. Mesenchymal stem/…

While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared
hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing stage of …

We are interested in the mechanisms of glial cell development in the vertebrate central nervous
system. We have identified genes that can direct the formation of glia in the retina. rax, a …

Nanotechnology manifests the progression in the arena of research and development, by
increasing the efficacy of the product through delivery of innovative solutions. To overcome …

Mutation of the RB-1 and p53 tumor suppressors is associated with the development of
human osteosarcoma. With the goal of generating a mouse model of this disease, we used …