User profiles for Sieger A. Nelemans

SA Nelemans

University of Groningen
Verified email at rug.nl
Cited by 2179

[HTML][HTML] Gut bacterial deamination of residual levodopa medication for Parkinson's disease

…, SL Winkel, SS van Leeuwen, SA Nelemans… - BMC biology, 2020 - Springer
Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized
by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the …

[HTML][HTML] Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

…, M Schwalbe, C Aranzamendi, SA Nelemans… - PLoS …, 2021 - journals.plos.org
Microbial conversion of dietary or drug substrates into small bioactive molecules represents
a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we …

Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats

…, CG Neochoritis, W Hoornenborg, SA Nelemans… - Gut …, 2023 - Taylor & Francis
Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the
host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-…

[PDF][PDF] DECIPHERING THE POTENCY OF 5-HYDROXYINDOLE STIMULATORY EFFECT ON THE RAT COLONIC SMOOTH MUSCLES AND ITS BINDING SITES ON …

…, W Hoornenborg, SA Nelemans… - That gut instinct …, 2022 - research.rug.nl
Dysregulation of L-type voltage-gated calcium channels (LTCCs) is associated with various
gastrointestinal motility disorders, including constipation, making LTCCs an important target …

[PDF][PDF] Gut bacterial deamination of residual levodopa medication for Parkinson's

…, SL Winkel, SS van Leeuwen, SA Nelemans… - 2020 - bmcbiol.biomedcentral.com
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder
characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of …

Search for high-energy neutrinos from binary neutron star merger GW170817 with ANTARES, IceCube, and the Pierre Auger Observatory

…, P Sapienza, F Schussler, C Sieger… - arXiv preprint arXiv …, 2017 - arxiv.org
The Advanced LIGO and Advanced Virgo observatories recently discovered gravitational
waves from a binary neutron star inspiral. A short gamma-ray burst (GRB) that followed the …

High-energy neutrino follow-up search of gravitational wave event GW150914 with ANTARES and IceCube

…, J Schnabel, F Schüssler, T Seitz, C Sieger… - Physical Review D, 2016 - APS
We present the high-energy-neutrino follow-up observations of the first gravitational wave
transient GW150914 observed by the Advanced LIGO detectors on September 14, 2015. We …

Search for high-energy neutrinos from gravitational wave event GW151226 and candidate LVT151012 with ANTARES and IceCube

…, M Sanguineti, P Sapienza, F Schüssler, C Sieger… - Physical review D, 2017 - APS
The Advanced LIGO observatories detected gravitational waves from two binary black hole
mergers during their first observation run (O1). We present a high-energy neutrino follow-up …

PARMA international protocol: pilot study on 50 patients and preliminary analysis of the ongoing randomized study (62 patients)

…, B Coiffier, C Gisselbrecht, JCK Nelemans… - Annals of oncology, 1991 - Elsevier
Fifty patients with intermediate- or high-grade non-Hodgkin's lymphoma who had relapsed
following a complete remission (CR) induced by a doxorubicin-containing chemotherapy …