User profiles for Siew-Kee Low
Siew-Kee LowJapanese Foundation for Cancer Research Tokyo, Japan Verified email at jfcr.or.jp Cited by 5447 |
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …
To elucidate disease biology in the East Asian population, we conducted a genome-wide …
Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…
Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …
Genome-wide association meta-analysis identifies new endometriosis risk loci
We conducted a genome-wide association meta-analysis of 4,604 endometriosis cases and
9,393 controls of Japanese 1 and European 2 ancestry. We show that rs12700667 on …
9,393 controls of Japanese 1 and European 2 ancestry. We show that rs12700667 on …
Genome-wide association study of intracranial aneurysm identifies three new risk loci
K Yasuno, K Bilguvar, P Bijlenga, SK Low, B Krischek… - Nature …, 2010 - nature.com
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall;
their hemorrhage commonly results in severe neurologic impairment and death. We report a …
their hemorrhage commonly results in severe neurologic impairment and death. We report a …
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death 1 , 2 . Fourteen genetic loci have been associated with atrial …
stroke, heart failure, and death 1 , 2 . Fourteen genetic loci have been associated with atrial …
[HTML][HTML] Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32. 1, 5q14. 3 and 15q26. 1
In a three-stage genome-wide association study among East Asian women including 22,780
cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer …
cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer …
A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma
Primary open angle glaucoma (POAG) is one of leading causes of adult blindness worldwide.
To identify genetic variants associated with susceptibility to POAG, we conducted a …
To identify genetic variants associated with susceptibility to POAG, we conducted a …