User profiles for Siew-Kee Low

Siew-Kee Low

Japanese Foundation for Cancer Research Tokyo, Japan
Verified email at jfcr.or.jp
Cited by 5447

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

…, H Sugishita, S Sakaue, N Matoba, SK Low… - Nature …, 2020 - nature.com
The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Multi-ethnic genome-wide association study for atrial fibrillation

…, ML Lokki, B London, RJF Loos, SK Low… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…

Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study

…, Y Li, V Mijatovic, Y Sapkota, SK Low… - JAMA …, 2017 - jamanetwork.com
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

…, DK Hapangama, C Hayward, AW Horne, SK Low… - Nature …, 2023 - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Genome-wide association meta-analysis identifies new endometriosis risk loci

DR Nyholt, SK Low, CA Anderson, JN Painter, S Uno… - Nature …, 2012 - nature.com
We conducted a genome-wide association meta-analysis of 4,604 endometriosis cases and
9,393 controls of Japanese 1 and European 2 ancestry. We show that rs12700667 on …

Genome-wide association study of intracranial aneurysm identifies three new risk loci

K Yasuno, K Bilguvar, P Bijlenga, SK Low, B Krischek… - Nature …, 2010 - nature.com
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall;
their hemorrhage commonly results in severe neurologic impairment and death. We report a …

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

…, NR Tucker, M Li, D Klarin, NA Bihlmeyer, SK Low… - Nature …, 2017 - nature.com
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death 1 , 2 . Fourteen genetic loci have been associated with atrial …

[HTML][HTML] Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

…, DR Velez Edwards, M Nyegaard, SK Low… - Nature …, 2017 - nature.com
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32. 1, 5q14. 3 and 15q26. 1

Q Cai, B Zhang, H Sung, SK Low, SS Kweon, W Lu… - Nature …, 2014 - nature.com
In a three-stage genome-wide association study among East Asian women including 22,780
cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer …

A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma

W Osman, SK Low, A Takahashi, M Kubo… - Human molecular …, 2012 - academic.oup.com
Primary open angle glaucoma (POAG) is one of leading causes of adult blindness worldwide.
To identify genetic variants associated with susceptibility to POAG, we conducted a …