[PDF][PDF] Derivation of human midbrain-specific organoids from neuroepithelial stem cells

AS Monzel, LM Smits, K Hemmer, S Hachi, EL Moreno… - Stem cell reports, 2017 - cell.com
Research on human brain development and neurological diseases is limited by the lack of
advanced experimental in vitro models that truly recapitulate the complexity of the human …

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture

EL Moreno, S Hachi, K Hemmer, SJ Trietsch… - Lab on a Chip, 2015 - pubs.rsc.org
A hallmark of Parkinson's disease is the progressive loss of nigrostriatal dopaminergic
neurons. We derived human neuroepithelial cells from induced pluripotent stem cells and …

[HTML][HTML] Automated microfluidic cell culture of stem cell derived dopaminergic neurons

KIW Kane, EL Moreno, S Hachi, M Walter, J Jarazo… - Scientific reports, 2019 - nature.com
Parkinson’s disease is a slowly progressive neurodegenerative disease characterised by
dysfunction and death of selectively vulnerable midbrain dopaminergic neurons and the …

[HTML][HTML] Determination of the rheological properties of Matrigel for optimum seeding conditions in microfluidic cell cultures

KIW Kane, E Lucumi Moreno, CM Lehr, S Hachi… - AIP Advances, 2018 - pubs.aip.org
Hydrogels are increasingly used as a surrogate extracellular matrix in three-dimensional cell
culture systems, including microfluidic cell culture. Matrigel is a hydrogel of natural origin …

[HTML][HTML] A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

L Mao, A Nicolae, MAP Oliveira, F He, S Hachi… - Computational and …, 2015 - Elsevier
One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons
in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration …

Sonographic dynamic description of the laryngeal tract: definition of quantitative measures to characterize vocal fold motion and estimation of their normal values

…, DS Lazard, M Lefort, S Hachi… - … of Ultrasound in …, 2017 - Wiley Online Library
Vocal fold motion was analyzed during free breathing using two‐dimensional dynamic
ultrasound imaging. Two cadavers were first analyzed to define easily identifiable landmarks. …

Detection of recurrent nerve paralysis: development of a computer aided diagnosis system

ME Cohen, M Lefort, H Bergeret-Cassagne, S Hachi… - IRBM, 2015 - Elsevier
Recurrent nerve paralysis (RP) is one of the most frequent complications of thyroid surgery.
It reduces vocal fold mobility. Nasal endoscopy, a mini-invasive procedure, is the reference …

Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson's Disease

E Lucumi Moreno, S Hachi, SL Nickels, KIW Kane… - BioRxiv, 2021 - biorxiv.org
Monogenic Parkinson’s Disease can be caused by a mutation in the leucine-rich repeat kinase
2 (LRRK2) gene, causing a late-onset autosomal dominant inherited form of Parkinson’s …

Automated microuidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease

KIW Kane, EL Moreno, S Hachi, M Walter, J Jarazo… - bioRxiv, 2017 - biorxiv.org
Parkinson’s disease is a slowly progressive neurodegenerative disease characterised by
dysfunction and death of selectively vulnerable midbrain dopaminergic neurons leading …

A novel approach to derive human midbrain-specific organoids from neuroepithelial stem cells

AS Monzel, LM Smits, K Hemmer, S Hachi… - BioRxiv, 2016 - biorxiv.org
Research on human brain development and neurological diseases is limited by the lack of
advanced experimental in vitro models that truly recapitulate the complexity of the human …