Autophagy is a homeostatic cellular process involved in the degradation of long-lived or
damaged cellular components. The role of autophagy in adipogenesis is well recognized, but its …

The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-γ
coactivator-1α (PGC-1α) was targeted in mice. PGC-1α null (PGC-1α −/− ) mice were …

Diabetes is associated with increased incidence of heart failure even after controlling for
coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become an …

Cardiovascular disease (CVD) is the number one cause of death in the United States.
Advancing age is a primary risk factor for developing CVD. Estimates indicate that 20% of the US …

Diabetes mellitus increases the risk of heart failure independently of underlying coronary
artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …

Pyruvate constitutes a critical branch point in cellular carbon metabolism. We have identified
two proteins, Mpc1 and Mpc2, as essential for mitochondrial pyruvate transport in yeast, …

Diabetes alters cardiac substrate metabolism. The cardiac phenotype in insulin-resistant states
has not been comprehensively characterized. The goal of these studies was to determine …

OBJECTIVE—In obesity and diabetes, myocardial fatty acid utilization and myocardial
oxygen consumption (MVo 2 ) are increased, and cardiac efficiency is reduced. Mitochondrial …

Background— Obesity is a risk factor for cardiovascular disease and is strongly associated
with insulin resistance and type 2 diabetes. Recent studies in obese humans and animals …

Background— Diabetes-associated cardiac dysfunction is associated with mitochondrial
dysfunction and oxidative stress, which may contribute to left ventricular dysfunction. The …