Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum,
and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is …

Metastasis is the defining feature of advanced malignancy, yet remains challenging to study
in laboratory environments. Here, we describe a high-throughput zebrafish system for …

Bacteriophage are voracious predators of bacteria and a major determinant in shaping
bacterial life strategies. Many phage species are virulent, meaning that infection leads to certain …

Many Proteobacteria use acyl-homoserine lactone (AHL)-mediated quorum sensing to activate
the production of antibiotics at high cell density. Extracellular factors like antibiotics can …

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a "go or grow" trade-off; however, how these …

Bacteria are highly social organisms that communicate via signaling molecules, move
collectively over surfaces and make biofilm communities. Nonetheless, our main line of defense …

Many bacteria secrete compounds which act as public goods. Such compounds are often
under quorum sensing (QS) regulation, yet it is not understood exactly when bacteria may gain …

Virulent phages and their bacterial hosts represent an unusual sort of predator-prey system
where each time a prey is eaten, hundreds of new predators are born. It is puzzling how, …

The mechanism of how organ shape emerges and specifies cell fate is not understood.
Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar …

Motivated by the challenging segmentation task of pancreatic tubular networks, this paper
tackles two commonly encountered problems in biomedical imaging: Topological consistency …