User profiles for Silja Heilmann
Silja HeilmannUniversity of Copenhagen, ICMM Verified email at sund.ku.dk Cited by 876 |
[HTML][HTML] Microenvironment-derived factors driving metastatic plasticity in melanoma
IS Kim, S Heilmann, ER Kansler, Y Zhang… - Nature …, 2017 - nature.com
Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum,
and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is …
and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is …
A quantitative system for studying metastasis using transparent zebrafish
S Heilmann, K Ratnakumar, EM Langdon, ER Kansler… - Cancer research, 2015 - AACR
Metastasis is the defining feature of advanced malignancy, yet remains challenging to study
in laboratory environments. Here, we describe a high-throughput zebrafish system for …
in laboratory environments. Here, we describe a high-throughput zebrafish system for …
Coexistence of phage and bacteria on the boundary of self-organized refuges
S Heilmann, K Sneppen… - Proceedings of the …, 2012 - National Acad Sciences
Bacteriophage are voracious predators of bacteria and a major determinant in shaping
bacterial life strategies. Many phage species are virulent, meaning that infection leads to certain …
bacterial life strategies. Many phage species are virulent, meaning that infection leads to certain …
Acyl-homoserine lactone-dependent eavesdropping promotes competition in a laboratory co-culture model
Many Proteobacteria use acyl-homoserine lactone (AHL)-mediated quorum sensing to activate
the production of antibiotics at high cell density. Extracellular factors like antibiotics can …
the production of antibiotics at high cell density. Extracellular factors like antibiotics can …
[PDF][PDF] Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation
…, L Briker, M Zhang, M Baron, S Heilmann… - Developmental cell, 2021 - cell.com
Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a "go or grow" trade-off; however, how these …
invasive (INV) subpopulations that represent a "go or grow" trade-off; however, how these …
Exploiting social evolution in biofilms
KE Boyle, S Heilmann, D van Ditmarsch… - Current opinion in …, 2013 - Elsevier
Bacteria are highly social organisms that communicate via signaling molecules, move
collectively over surfaces and make biofilm communities. Nonetheless, our main line of defense …
collectively over surfaces and make biofilm communities. Nonetheless, our main line of defense …
[HTML][HTML] Why do bacteria regulate public goods by quorum sensing?—How the shapes of cost and benefit functions determine the form of optimal regulation
Many bacteria secrete compounds which act as public goods. Such compounds are often
under quorum sensing (QS) regulation, yet it is not understood exactly when bacteria may gain …
under quorum sensing (QS) regulation, yet it is not understood exactly when bacteria may gain …
Sustainability of virulence in a phage-bacterial ecosystem
Virulent phages and their bacterial hosts represent an unusual sort of predator-prey system
where each time a prey is eaten, hundreds of new predators are born. It is puzzling how, …
where each time a prey is eaten, hundreds of new predators are born. It is puzzling how, …
[PDF][PDF] p120ctn-mediated organ patterning precedes and determines pancreatic progenitor fate
P Nyeng, S Heilmann, ZM Löf-Öhlin, NF Pettersson… - Developmental cell, 2019 - cell.com
The mechanism of how organ shape emerges and specifies cell fate is not understood.
Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar …
Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar …
Quantifying topology in pancreatic tubular networks from live imaging 3D microscopy
Motivated by the challenging segmentation task of pancreatic tubular networks, this paper
tackles two commonly encountered problems in biomedical imaging: Topological consistency …
tackles two commonly encountered problems in biomedical imaging: Topological consistency …