Background: Data for multiple common susceptibility alleles for breast cancer may be combined
to identify women at different levels of breast cancer risk. Such stratification could guide …

Genome-wide association studies (GWAS) and large-scale replication studies have identified
common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial …

In the preceding decades, molecular characterization has revolutionized breast cancer (BC)
research and therapeutic approaches. Presented herein, an unbiased analysis of breast …

We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen
receptor α) in 118,816 subjects from three international consortia. We found evidence for at …

MicroRNAs (miRNAs) are endogenous non-coding RNAs, which play an essential role in the
regulation of gene expression during carcinogenesis. The role of miRNAs in breast cancer …

GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine
mapping of this locus using data from 101,943 subjects from 50 case-control studies. We …

Common variants in 94 loci have been associated with breast cancer including 15 loci with
genome-wide significant associations (P<5 × 10 −8 ) with oestrogen receptor (ER)-negative …

Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In
this study we integrate classifications extracted from five different molecular levels in order …

Background Single-cell micro-metastases of solid tumors often occur in the bone marrow.
These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to …

Alterations in glycan structures are early signs of malignancy and have recently been proposed
to be in part a driving force behind malignant transformation. Here, we explore whether …