User profiles for Silvain Pinaud

Silvain Pinaud

CRCN, IRD, Montpellier, France
Verified email at ird.fr
Cited by 761

Innate immune memory: An evolutionary perspective

B Gourbal, S Pinaud, GJM Beckers… - Immunological …, 2018 - Wiley Online Library
Over the last decades, there was increasing evidence for the presence of innate immune
memory in living organisms. In this review, we compare the innate immune memory of various …

Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP-SmPoMuc interaction

A Portet, S Pinaud, G Tetreau, R Galinier… - Developmental & …, 2017 - Elsevier
The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen
Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In …

ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

…, A Tsyben, G Hamm, J Stockis, C Garcia, S Pinaud… - Nature …, 2020 - nature.com
Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a
commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid …

[HTML][HTML] A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata

S Pinaud, J Portela, D Duval, FC Nowacki… - PLoS …, 2016 - journals.plos.org
Discoveries made over the past ten years have provided evidence that invertebrate antiparasitic
responses may be primed in a sustainable manner, leading to the failure of a secondary …

[HTML][HTML] A microsporidian impairs Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes

…, MV Mancini, JW Oundo, ET Teal, S Pinaud… - Nature …, 2020 - nature.com
A possible malaria control approach involves the dissemination in mosquitoes of inherited
symbiotic microbes to block Plasmodium transmission. However, in the Anopheles gambiae …

[HTML][HTML] Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

…, M Zarocsinceva, K Kania, J Stockis, S Pinaud… - Nature …, 2021 - nature.com
It is unclear how genetic aberrations impact the state of nascent tumour cells and their
microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise …

[HTML][HTML] Specific pathogen recognition by multiple innate immune sensors in an invertebrate

G Tetreau, S Pinaud, A Portet, R Galinier… - Frontiers in …, 2017 - frontiersin.org
Detection of pathogens by all living organisms is the primary step needed to implement a
coherent and efficient immune response. This implies a mediation by different soluble and/or …

[HTML][HTML] BgTEP: An Antiprotease Involved in Innate Immune Sensing in Biomphalaria glabrata

A Portet, R Galinier, S Pinaud, J Portela… - Frontiers in …, 2018 - frontiersin.org
Insect thioester-containing protein (iTEP) is the most recently defined group among the
thioester-containing protein (TEP) superfamily. TEPs are key components of the immune system, …

[HTML][HTML] A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni

…, Y Moné, D Duval, A Portet, S Pinaud… - PLoS neglected …, 2017 - journals.plos.org
In recent decades, numerous studies have sought to better understand the mechanisms
underlying the compatibility between Biomphalaria glabrata and Schistosoma mansoni. The …

Molecular characterisation of immunological memory following homologous or heterologous challenges in the schistosomiasis vector snail, Biomphalaria glabrata

S Pinaud, A Portet, JF Allienne, L Belmudes… - Developmental & …, 2019 - Elsevier
Invertebrate immune response may be primed by a current infection in a sustained manner,
leading to the failure of a secondary infection with the same pathogen. The present study …