Background & aims Old persons are more likely to suffer from malnutrition, which may result
in higher dependency in activities of daily living. We aimed to provide a quantitative …

Stem cell persistence into adulthood requires self-renewal from early developmental stages.
In the developing mouse brain, only apical progenitors located at the ventricle are self-…

Self-organizing three-dimensional cellular models derived from human pluripotent stem
cells or primary tissue have great potential to provide insights into how the human nervous …

Neurotrophins play an important role in modulating activity-dependent neuronal plasticity. In
particular, threshold levels of brain-derived neurotrophic factor (BDNF) are required to …

Evolution of the mammalian brain encompassed a remarkable increase in size of the
cerebral cortex, which includes tangential and radial expansion. However, the mechanisms …

The regulated proliferation and differentiation of neural stem cells before the generation and
migration of neurons in the cerebral cortex are central aspects of mammalian development. …

The positioning of neurons in the cerebral cortex is of crucial importance for its function as
highlighted by the severe consequences of migrational disorders in patients. Here we show …

Cerebral cortex size differs dramatically between reptiles, birds, and mammals, owing to
developmental differences in neuron production. In mammals, signaling pathways regulating …

Malformations of the human cortex represent a major cause of disability 1 . Mouse models
with mutations in known causal genes only partially recapitulate the phenotypes and are …

… Author links open overlay panel Emanuele Cereda a , Silvia Cappello a , Sara Colombo b ,
Catherine Klersy c , Ilaria Imarisio d , Annalisa Turri a , Marilisa Caraccia a , Valeria Borioli a , …