The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that
regulates cell fate by transducing a myriad of growth-factor signals 1 . The ability of this …

Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm
to the nucleus. Positive feedback loops regulate the activation of Cdk1-cyclin B1 and help …

The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse
cues and swiftly determines appropriate cellular responses. However, our understanding of …

Cell division is characterized by a sequence of events by which a cell gives rise to two
daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that …

During early development, extrinsic triggers prompt pluripotent cells to begin the process of
differentiation. When and how human embryonic stem cells (hESCs) irreversibly commit to …

Mammalian genomes harbor abundant transposable elements (TEs) and their remnants, with
numerous epigenetic repression mechanisms enacted to silence TE transcription. However…

Cell division is a fundamental cellular process and the evolutionarily conserved networks
that control cell division cycles adapt during development, tissue regeneration, cell de‐…

Protein synthesis inhibitors (eg, cycloheximide) block mitotic entry, suggesting that cell cycle
progression requires protein synthesis until right before mitosis. However, cycloheximide is …

… Silvia DM Santos … Silvia DM Santos and James E. Ferrell are in the Department of
Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California …

Chromatin immunoprecipitation (ChIP) followed by next-generation sequencing is a powerful
technique that characterizes the genome-wide DNA-binding profile of a protein of interest. …