For efficient transcription, RNA PolII must overcome the presence of nucleosomes. The p38‐related
MAPK Hog1 is an important regulator of transcription upon osmostress in yeast and …

Mutations in chromatin modifier genes are frequently associated with neurodevelopmental
diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (…

The maintenance of genomic stability requires the coordination of multiple cellular tasks upon
the appearance of DNA lesions. RNA editing, the post-transcriptional sequence alteration …

RNA polymerase II (RNAPII) transcription elongation is a highly regulated process that greatly
influences mRNA levels as well as pre-mRNA splicing. Despite many studies in vitro, how …

Termination of RNA polymerase II (RNAPII) transcription of protein-coding genes occurs
downstream of cleavage/polyadenylation sites. According to the "torpedo" model, the 5′-3′ …

Chromatin distribution is not uniform along the human genome. In most genes there is a
promoter-associated nucleosome free region (NFR) followed by an array of nucleosomes …

Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance
of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain …

Transcription elongation by RNA polymerase II was often considered an invariant non-regulated
process. However, genome-wide studies have shown that transcriptional pausing …

Histone proteins are main structural components of the chromatin and major determinants of
gene regulation. Expression of canonical histone genes is strictly controlled during the cell …

The ATM kinase is a master regulator of the DNA damage response to double-strand
breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the …