Cells perceive their microenvironment not only through soluble signals but also through
physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined …

Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …

The Hippo transducers YAP/TAZ have been shown to play positive, as well as negative,
roles in Wnt signaling, but the underlying mechanisms remain unclear. Here, we provide …

YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and tumorigenesis.
Yet, their function as transcriptional regulators remains underinvestigated. By ChIP-seq …

Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance
and immunotherapy. While tumor-recruited CD11b + myeloid cells are known mediators …

TGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted
into potent prometastatic factors in advanced cancers. The molecular nature of this switch …

Tumor growth is associated with a profound alteration in myelopoiesis, leading to recruitment
of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). We …

Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA
downregulation is a common trait of human malignancies. The mechanisms of this phenomenon …

Regulation of tryptophan metabolism by indoleamine 2,3-dioxygenase (IDO) in dendritic cells
(DCs) is a highly versatile modulator of immunity. In inflammation, interferon-γ is the main …

Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused
by mutations in genes encoding the basement membrane component laminin-332. Surviving …