Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether
this risk extends to all invasive histological subtypes or borderline tumours is not clear. We …

Polycomb group proteins (PCGs) are involved in repression of genes that are required for
stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) …

Families with autosomal dominant inherited predisposition to gastric cancer have been
described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary …

The EP300 protein is a histone acetyltransferase 1, 2 that regulates transcription via chromatin
remodelling 3 and is important in the processes of cell proliferation 4 and differentiation 5. …

Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 -…

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Mutations in the BRCA1 gene, discovered in 1994, are associated with an 80–90% lifetime
risk of breast cancer. We have analysed 60 families with a history of breast and/or ovarian …

The breast cancer susceptibility gene BRCA2 on chromosome 13q12–13 has recently been
identified1. Germline mutations of BRCA2 are predicted to account for approximately 35% of …

Importance Limited information about the relationship between specific mutations
inBRCA1orBRCA2(BRCA1/2) and cancer risk exists. Objective To identify mutation-specific cancer …

1 Nature America, Inc. All rights reserv ed. perspective 514 volume 43| number 6| june 2011|
NATURE GENETICS region if a similar association was found in this population, as the …