Dynamics of CTCF-and cohesin-mediated chromatin looping revealed by live-cell imaging

M Gabriele, HB Brandão, S Grosse-Holz, A Jha… - Science, 2022 - science.org
Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF
and loop-extruding cohesins, but the live dynamics of loop formation and stability remain …

Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics

VIP Keizer, S Grosse-Holz, M Woringer, L Zambon… - Science, 2022 - science.org
Our understanding of the physical principles organizing the genome in the nucleus is limited
by the lack of tools to directly exert and measure forces on interphase chromosomes in vivo …

Signatures of irreversibility in microscopic models of flocking

F Ferretti, S Grosse-Holz, C Holmes, JL Shivers… - Physical Review E, 2022 - APS
Flocking in d= 2 is a genuine nonequilibrium phenomenon for which irreversibility is an
essential ingredient. We study a class of minimal flocking models whose only source of …

Scale-free models of chromosome structure, dynamics, and mechanics

S Grosse-Holz, A Coulon, L Mirny - bioRxiv, 2023 - biorxiv.org
Scale-free, or fractal, models are prevalent in the study of chromosome structure, dynamics,
and mechanics. Recent experiments suggest the existence of scaling relationships; but …

[HTML][HTML] Spot quantification in two dimensional gel electrophoresis image analysis: comparison of different approaches and presentation of a novel compound fitting …

JM Brauner, TW Groemer, A Stroebel, S Grosse-Holz… - BMC …, 2014 - Springer
Background Various computer-based methods exist for the detection and quantification of
protein spots in two dimensional gel electrophoresis images. Area-based methods are …

Surface trafficking of APP and BACE in live cells

A Bauereiss, O Welzel, J Jung, S GrosseHolz… - Traffic, 2015 - Wiley Online Library
Amyloid‐β (Aβ)‐peptide, the major constituent of the plaques that develop during Alzheimer's
disease, is generated via the cleavage of Aβ precursor protein ( APP ) by β‐site APP ‐…

Electroconvulsive therapy hasn't negative effects on short-term memory function, as assessed using a bedside hand-held device

HHO Müller, M Reike, S Grosse-Holz, M Röther… - Mental illness, 2017 - emerald.com
Electroconvulsive therapy (ECT) is effective in the treatment of treatment-resistant major
depression. The fear of cognitive impairment after ECT often deters patients from choosing this …

Dynamics of Genome Organization

SB Grosse-Holz - 2023 - dspace.mit.edu
A human cell contains about 2m of DNA, packed into a nucleus with diameter ~10μm. The
three-dimensional structure of this packing has been the subject of intense investigation …

Gravitational effects in birefringent quantum electrodynamics

S Grosse-Holz, FP Schuller, R Tanzi - arXiv preprint arXiv:1703.07183, 2017 - arxiv.org
The most general classical electrodynamics which still respect the linear superposition
principle but allow for otherwise arbitrary birefringence require, and imply, a refined spacetime …

Aspects of integrability in a classical model for non-interacting fermionic fields

S Grosse-Holz, T Engl, K Richter, JD Urbina - arXiv preprint arXiv …, 2015 - arxiv.org
In this work we investigate the issue of integrability in a classical model for noninteracting
fermionic fields. This model is constructed via classical-quantum correspondence obtained …