[HTML][HTML] Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia …
S Hultmark, A Baudet, L Schmiderer, P Prabhala… - …, 2021 - ncbi.nlm.nih.gov
Combination treatment has proven effective for patients with acute promyelocytic leukemia,
exemplifying the importance of therapy targeting multiple components of oncogenic …
exemplifying the importance of therapy targeting multiple components of oncogenic …
Small molecule screening of primary human acute myeloid leukemia using co-culture and multiplexed FACS analysis
A Baudet, S Hultmark, F Ek, M Magnusson - Bio-protocol, 2022 - bio-protocol.org
Ex vivo culture of primary acute myeloid leukemia (AML) cells is notoriously difficult due to
spontaneous differentiation and cell death, which hinders mechanistic and translational …
spontaneous differentiation and cell death, which hinders mechanistic and translational …
[HTML][HTML] Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations
…, A Baudet, A Bäckström, E Arvidsson, S Hultmark… - …, 2022 - ncbi.nlm.nih.gov
Acute myeloid leukemia (AML) is a heterogeneous disorder and mostly incurable due to relapse
and drug resistance. A key challenge is to target the fraction of more quiescent leukemic …
and drug resistance. A key challenge is to target the fraction of more quiescent leukemic …
[HTML][HTML] Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy.
S Hultmark - 2022 - portal.research.lu.se
The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is
that they can restore normal hematopoiesis in patients that need a new blood system. Since …
that they can restore normal hematopoiesis in patients that need a new blood system. Since …
Hepatic leukemia factor is essential for maintaining hematopoietic stem cell function
K Komorowska, A Doyle, S Soneji, S Hultmark… - Experimental …, 2015 - exphem.org
The transcription factor hepatic leukemia factor (HLF) was originally identified in a chromosomal
translocation with E2A, causing childhood ALL. This form of ALL has poor prognosis …
translocation with E2A, causing childhood ALL. This form of ALL has poor prognosis …
Hepatic Leukemia Factor supports the propagation of leukemia and hematopoietic stem cell function during stress-induced regeneration
A Baudet, K Komorowska, S Hultmark, M Chapellier… - bioRxiv, 2021 - biorxiv.org
The processes regulating hematopoietic stem cells (HSC) during aging are not fully understood
1 , but it is clear that the incidence of hematological malignancies increases with age, …
1 , but it is clear that the incidence of hematological malignancies increases with age, …
[HTML][HTML] Hepatic Leukemia Factor Is Critical for Hematopoietic Stem Cells and Promotes MLL-AF9 Acute Myeloid Leukemia
A Baudet, KP Komorowska, H Simon, M Järås… - Blood, 2019 - Elsevier
The transcription factor Hepatic leukemia factor (HLF), initially identified as part of a leukemic
fusion protein (E2A-HLF) causing B-lymphoid leukemia in children, is expressed in a wide …
fusion protein (E2A-HLF) causing B-lymphoid leukemia in children, is expressed in a wide …
PEDF regulates hematopoietic stem cell maintenance
E Rorby, M Billing, M Dahl, S Hultmark… - Experimental …, 2014 - exphem.org
Background: Rituximab is an often effective treatment of ITP (Immune thrombocytopenia).
However treated patients who respond often relapse. While they may have an almost identical …
However treated patients who respond often relapse. While they may have an almost identical …
Erythroid cells use endosome-derived iron via the direct interaction of endosomes with mitochondria for heme synthesis
Background: Rituximab is an often effective treatment of ITP (Immune thrombocytopenia).
However treated patients who respond often relapse. While they may have an almost identical …
However treated patients who respond often relapse. While they may have an almost identical …
Three-dimensional multicolor imaging of bone marrow cell populations
Bone marrow (BM) is a complex tissue comprising many different cell types including bone,
stromal, endothelial, adipose and hematopoietic cells. It plays a key role in adult …
stromal, endothelial, adipose and hematopoietic cells. It plays a key role in adult …