User profiles for Simon L. Currie
 | Simon CurriePostdoctoral researcher, University of Texas Southwestern Medical Center Verified email at utsouthwestern.edu Cited by 526 |
[HTML][HTML] Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
Quantitative reconstitution of yeast RNA processing bodies
SL Currie, W Xing, D Muhlrad… - Proceedings of the …, 2023 - National Acad Sciences
Many biomolecular condensates appear to form through liquid–liquid phase separation (LLPS).
Individual condensate components can often undergo LLPS in vitro, capturing some …
Individual condensate components can often undergo LLPS in vitro, capturing some …
Using quantitative reconstitution to investigate multicomponent condensates
Many biomolecular condensates are thought to form via liquid–liquid phase separation (LLPS)
of multivalent macromolecules. For those that form through this mechanism, our …
of multivalent macromolecules. For those that form through this mechanism, our …
ETV4 and AP1 transcription factors form multivalent interactions with three sites on the MED25 activator-interacting domain
The recruitment of transcriptional cofactors by sequence-specific transcription factors challenges
the basis of high affinity and selective interactions. Extending previous studies that the N…
the basis of high affinity and selective interactions. Extending previous studies that the N…
Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor
…, CA Meeker, N Bhachech, SL Currie… - Proceedings of the …, 2014 - National Acad Sciences
The E26 transformation-specific (Ets-1) transcription factor is autoinhibited by a conformationally
disordered serine-rich region (SRR) that transiently interacts with its DNA-binding ETS …
disordered serine-rich region (SRR) that transiently interacts with its DNA-binding ETS …
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5
Autoinhibition enables spatial and temporal regulation of cellular processes by coupling
protein activity to surrounding conditions, often via protein partnerships or signaling pathways. …
protein activity to surrounding conditions, often via protein partnerships or signaling pathways. …
[HTML][HTML] Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct
Aberrant formation of biomolecular condensates has been proposed to play a role in several
cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes …
cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes …
[HTML][HTML] Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN–FOS at composite DNA sites
Many different transcription factors (TFs) regulate gene expression in a combinatorial
fashion, often by binding in close proximity to each other on composite cis-regulatory DNA …
fashion, often by binding in close proximity to each other on composite cis-regulatory DNA …
[HTML][HTML] Interaction of the Jhd2 histone H3 Lys-4 demethylase with chromatin is controlled by histone H2A surfaces and restricted by H2B ubiquitination
…, C Pflueger, TJ Parnell, MM Kasten, SL Currie… - Journal of Biological …, 2015 - ASBMB
Histone H3 lysine 4 (H3K4) methylation is a dynamic modification. In budding yeast, H3K4
methylation is catalyzed by the Set1-COMPASS methyltransferase complex and is removed …
methylation is catalyzed by the Set1-COMPASS methyltransferase complex and is removed …
Depicting a cellular space occupied by condensates
Condensates have emerged as a new way to understand how cells are organized, and have
been invoked to play crucial roles in essentially all cellular processes. In this view, the cell …
been invoked to play crucial roles in essentially all cellular processes. In this view, the cell …