Inflammatory bowel disease: cause and immunobiology

DC Baumgart, SR Carding - The Lancet, 2007 - thelancet.com
Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

[HTML][HTML] Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

…, T Snelling, UK Umlai, JK Nicholson, SR Carding… - Microbiome, 2018 - Springer
Background Gut microbiota composition and function are symbiotically linked with host
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …

γδ T cells: functional plasticity and heterogeneity

SR Carding, PJ Egan - Nature reviews immunology, 2002 - nature.com
γδ T cells remain an enigma. They are capable of generating more unique antigen receptors
than αβ T cells and B cells combined, yet their repertoire of antigen receptors is dominated …

Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia.

M Buschle, D Campana, SR Carding… - The Journal of …, 1993 - rupress.org
The malignant, CD5+ B lymphocytes of B cell chronic lymphocytic leukemia (B-CLL) die by
apoptosis in vitro. This is in contrast to the prolonged life span of the leukemic cells in vivo …

Roles of alphabeta and gammadelta T cell subsets in viral immunity

…, W Allan, M Eichelberger, SR Carding - Annual review of …, 1992 - annualreviews.org
The current status of T-cell subset involvement in viral immunity is summarized for experimental
studies in mice. The immunobiology of the normal host response is discussed, with …

The WD 40 domain of ATG 16L1 is required for its non‐canonical role in lipidation of LC 3 at single membranes

…, U Mayer, SR Carding, T Wileman, R Beale… - The EMBO …, 2018 - embopress.org
A hallmark of macroautophagy is the covalent lipidation of LC 3 and insertion into the double‐membrane
phagophore, which is driven by the ATG 16L1/ ATG 5‐ ATG 12 complex. In …

The gut virome: the 'missing link'between gut bacteria and host immunity?

I Mukhopadhya, JP Segal, SR Carding… - Therapeutic …, 2019 - journals.sagepub.com
The human gut virome includes a diverse collection of viruses that infect our own cells as
well as other commensal organisms, directly impacting on our well-being. Despite its …

Outer membrane vesicles: biogenesis, functions, and issues

R Juodeikis, SR Carding - Microbiology and Molecular Biology …, 2022 - Am Soc Microbiol
This review focuses on nonlytic outer membrane vesicles (OMVs), a subtype of bacterial
extracellular vesicles (BEVs) produced by Gram-negative organisms focusing on the …

Intraepithelial γδ+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection

…, B Striepen, JE Smith, SJ White, SR Carding - Gastroenterology, 2006 - Elsevier
Background & Aims: Intestinal epithelial integrity and permeability is dependent on intercellular
tight junction (TJ) complexes. How TJ integrity is regulated remains unclear, although …