User profiles for Simon Zhongyuan Tian
 | Simon Zhongyuan TianSUStech Verified email at sustech.edu.cn Cited by 1393 |
[PDF][PDF] CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription
Spatial genome organization and its effect on transcription remains a fundamental question.
We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA…
We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA…
Multiplex chromatin interactions with single-molecule precision
The genomes of multicellular organisms are extensively folded into 3D chromosome territories
within the nucleus 1 . Advanced 3D genome-mapping methods that combine proximity …
within the nucleus 1 . Advanced 3D genome-mapping methods that combine proximity …
Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions
Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) is a robust method
for capturing genome-wide chromatin interactions. Unlike other 3C-based methods, it …
for capturing genome-wide chromatin interactions. Unlike other 3C-based methods, it …
[HTML][HTML] Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response
Mechanical signals from the extracellular microenvironment have been implicated in tumor
and metastatic progression. Here, we identify nucleoporin NUP210 as a metastasis …
and metastatic progression. Here, we identify nucleoporin NUP210 as a metastasis …
MCIBox: a toolkit for single-molecule multi-way chromatin interaction visualization and micro-domains identification
The emerging ligation-free three-dimensional (3D) genome mapping technologies can identify
multiplex chromatin interactions with single-molecule precision. These technologies not …
multiplex chromatin interactions with single-molecule precision. These technologies not …
[HTML][HTML] Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia
Background Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion
protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms …
protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms …
[HTML][HTML] Pore‐C simultaneously captures genome‐wide multi‐way chromatin interaction and associated DNA methylation status in Arabidopsis
… Zhuowen Li, 1 , 2 , 3 , † Yanping Long, 1 , 2 , 3 , † Yiming Yu, 1 , 2 , 3 Fei Zhang, 1 , 2 , 3
Hong Zhang, 1 , 2 , 3 Zhijian Liu, 1 , 2 , 3 Jinbu Jia, 1 , 2 , 3 Weipeng Mo, 1 , 2 , 3 Simon …
Hong Zhang, 1 , 2 , 3 Zhijian Liu, 1 , 2 , 3 Jinbu Jia, 1 , 2 , 3 Weipeng Mo, 1 , 2 , 3 Simon …
ScSmOP: a universal computational pipeline for single-cell single-molecule multiomics data analysis
…, G Huang, Y Deng, G Chen, G Li, SZ Tian… - Briefings in …, 2023 - academic.oup.com
Single-cell multiomics techniques have been widely applied to detect the key signature of
cells. These methods have achieved a single-molecule resolution and can even reveal spatial …
cells. These methods have achieved a single-molecule resolution and can even reveal spatial …
[HTML][HTML] MIA-Sig: multiplex chromatin interaction analysis by signal processing and statistical algorithms
The single-molecule multiplex chromatin interaction data are generated by emerging 3D
genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets provide …
genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets provide …
[HTML][HTML] MCI-frcnn: A deep learning method for topological micro-domain boundary detection
SZ Tian, P Yin, K Jing, Y Yang, Y Xu… - Frontiers in Cell and …, 2022 - frontiersin.org
Chromatin structural domains, or Topologically Associated Domains (TADs), are a general
organizing principle in chromatin biology. RNA polymerase II (RNAPII) mediated multiple …
organizing principle in chromatin biology. RNA polymerase II (RNAPII) mediated multiple …