Pancreatic insulin-producing β-cells have a long lifespan, such that in healthy conditions
they replicate little during a lifetime. Nevertheless, they show increased self-duplication after …

Total or near-total loss of insulin-producing β-cells occurs in type 1 diabetes 1 , 2 . Restoration
of insulin production in type 1 diabetes is thus a major medical challenge. We previously …

Decapitated Hydra regenerate their heads via morphallaxis, ie, without significant contributions
made by cell proliferation or interstitial stem cells. Indeed, Hydra depleted of interstitial …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

Insulin-producing pancreatic β cells in mice can slowly regenerate from glucagon-producing
α cells in settings like β cell loss, but the basis of this conversion is unknown. Moreover, it …

New perspectives on the origin of neurogenesis emerged with the identification of genes
encoding post-synaptic proteins as well as many “neurogenic” regulators as the NK, Six, Pax, …

The dogma that life without insulin is incompatible has recently been challenged by results
showing the viability of insulin-deficient rodents undergoing leptin monotherapy. Yet, the …

OBJECTIVE To evaluate whether healthy or diabetic adult mice can tolerate an extreme
loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and …

The Hydra model system is well suited for the eludication of the mechanisms underlying
regeneration in the adult, and an understanding of the core mechanisms is likely to cast light on …

Because head regeneration occurs in nerve-free hydra mutants, neurogenesis was regarded
as dispensable for this process. Here, in wild-type hydra, we tested the function of the …