The rational design of enzymes is an important goal for both fundamental and practical
reasons. Here, we describe a process to learn the constraints for specifying proteins purely from …

Complexity of neural systems often makes impracticable explicit measurements of all interactions
between their constituents. Inverse statistical physics approaches, which infer effective …

In the course of evolution, proteins undergo important changes in their amino acid
sequences, while their three-dimensional folded structure and their biological function remain …

10.7554/eLife.39397.001 Statistical analysis of evolutionary-related protein sequences
provides information about their structure, function, and history. We show that Restricted …

The hippocampus is known to store cognitive representations, or maps, that encode both
positional and contextual information, critical for episodic memories and functional behavior. …

Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more
immunogenic cancer cells to cause less immunogenic clones to dominate a population. …

We analyze whether the “overstretched,” or “S” form of double-stranded DNA consists of
essentially separated, or essentially interacting, polynucleotide strands. Comparison of force-…

A theory of the unzipping of double-stranded DNA is presented and is compared to recent
micromanipulation experiments. It is shown that the interactions that stabilize the double helix …

We present a new dynamical model of DNA. This model has two degrees of freedom per
base-pair: one radial variable related to the opening of the hydrogen bonds and an angular one …

We introduce a procedure to infer the interactions among a set of binary variables, based on
their sampled frequencies and pairwise correlations. The algorithm builds the clusters of …