Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

The regenerative potential of mammalian peripheral nervous system neurons after injury is
critically limited by their slow axonal regenerative rate 1 . Regenerative ability is influenced …

Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by
the inflammatory response after injury. Here we show that ROS, which promote axonal …

Traumatic brain injury (TBI) causes neuronal apoptosis, inflammation, and reactive
astrogliosis, which contribute to secondary tissue loss, impaired regeneration, and associated …

Aging is associated with increased prevalence of axonal injuries characterized by poor
regeneration and disability. However, the underlying mechanisms remain unclear. In our …

Axon regeneration is substantially regulated by gene expression and cytoskeleton remodeling.
Here we show that the tumor suppressor protein p53 is required for neurite outgrowth in …

Spinal cord injury causes secondary biochemical changes leading to neuronal cell death. To
clarify the molecular basis of this delayed injury, we subjected rats to spinal cord injury and …

The activity of the p53 gene product is regulated by a plethora of posttranslational
modifications. An open question is whether such posttranslational changes act redundantly or …

Neuronal outgrowth is guided by both extrinsic and intrinsic factors, involving transcriptional
regulation. The acetylation of histones and transcription factors, which facilitates promoter …

Axonal injury results in regenerative success or failure, depending on whether the axon lies
in the peripheral or the CNS, respectively. The present study addresses whether epigenetic …